PD Drugs (brand name vs generics) and PD vs Weather

The other day one of Mario's Twitter friends asked him if the change in weather bothered my Parkinson's Disease.    I then did some research both thru "The Parkinson's Disease Treatment Book" by J. Eric Ahlskog, M.D. Mayo Clinic Parkinson Specialist, and thru http://www.parkinson.org/.   I could not find any reference to weather playing a role in Parkinson's Disease.  It doesn't seem to affect me either - but read on......

However, i do have arthritis in many of my joints and spine.   I can tell you without a doubt that weather does impact my arthritis.   The past couple of mornings I have awaken to a very sore, stiff body and it has been difficult to get moving.   So, thank heavens for the Tramadol and Tylenol combination my family doctor prescribed.   

While doing the research on Weather/Parkinson's, I happened on an article published in http://www.parkinson.org/.  In an article (half way down the page on the left hand side) - click on:

• Generic vs. Branded Drugs for Parkinson’s Disease

The following paragraphs were copied from that article:

"Currently, there are multiple pharmaceutical companies that manufacture a generic formulation of carbidopa/levodopa, dopamine agonists, monoamine oxidase inhibitors and anticholinergics. If you have Parkinson’s, are taking brand name medication and then are offered a generic substitution for one of your Parkinson’s medications, you should know that the FDA requires that generic drugs must show an “essential similarity” to the branded drug prior to market approval, but that in some cases, this standard is not high enough. A review supported by NPF chronicles compelling evidence that if you are in more advanced stages of the disease, switching from branded drugs to generic, or from one generic to another, may have adverse effects. The authors, including NPF National Medical Director Dr. Michael S. Okun, believe that the standards for approving generic drugs for Parkinson's may not be strict enough to demonstrate that the generic alternatives are equally effective."

"Work with your physician to develop a tailored treatment plan. Using generic drugs may provide a cost savings, but they may not be appropriate for you, especially if you already tolerate the branded drug.
If you make the switch, be sure to follow these tips:

• Report to your physician how effective the drug is
• Carefully keep a diary of any side effects
• Record dose adjustments that your physicians make (higher or lower)
• In general, try to stay with a single drug manufacturer for your generic medications (You may need to ask your pharmacist to special order for you)

When attempts to tailor drug therapy with a generic drug have been unsuccessful, have your doctor appeal to the insurance company for a branded drug. It is important to include meticulous details of the various adverse side effects with the generic medication in your appeal letter."

So this article supports the problems I experienced when the doctor switched me from the Brand name Mirapex to the generic one.  My system couldn't tolerate it and it wasn't my imagination.   Many of my readers also confirmed they many times they have had problems with generics.  This is not to say that generics are bad.  They are not, but if they don't work for you, then they don't work for you.  Tell your doctor.   This may be why I had problems with the generic levodopa/carbidopa drug that the doctor tried me on, which was also a generic.   I will be talking to him about that and am printing off a copy of this article to take with me.


In my opinion, doctor's are beginning to prescribe more and more generics because


1.  It does save the patient money. but, more importantly......
2.  The Insurance Companies prefer the use of generics to save money.  If a brand name is prescribed, the doctor has to jump through hoops to request the brand name.  They are already over booked with patients and just don't have time for the added paper work.   Strictly my opinion, not based on fact but seems to be what happens in my case.  


Thanks for reading about this subject again.  But I had to document what I found to back up my comments on the problems I was having.  


Mary